(2008b). Many of these compounds are being studied for their potential anti-cancer effects. Here are the summary learning points: Your doctor or health care provider may recommend that you consider 500mg of Resveratrol with yourmeloxicam (anti-inflammatory) prescription. reported that a CU had a potential effective action on . Byun H. S., Song J. K., Kim Y. R., Piao L., Won M., Park K. A., et al. On the other hand, BK/B2R/PKC Pathway and Nrf2/ARE/ROS pathway can act on downstream MAPK, which can mediate AP-1 and NF-B, thus forming a closed loop of complex signaling pathways starting from the SIRT1 pathway. Alivernini S., Kurowska-Stolarska M., Tolusso B., Benvenuto R., Elmesmari A., Canestri S., et al. Resveratrol supplements may help lower blood pressure by increasing the production of nitric oxide. The problem with osteoarthritis is that this cartilage is not replaced. At present, many reviews on resveratrol have clarified its anti-cancer (Carter et al., 2014) and anti-cardiovascular disease effects. SIRT1 can downregulate NF-B and MMP1/MMP13, both of which promote the invasion of RA. Many supplements come with recommended storage suggestions on the product label, though not all do. Journal of the Science of Food and Agriculture. These benefits include increasing insulin sensitivity and preventing complications from diabetes (26, 27, 28, 29). (2015). After six months of treatment, their LDL had gone down by 4.5% and their oxidized LDL had gone down by 20% compared to participants who took an unenriched grape extract or a placebo (15). We create healing inflammation that stimulates the bodys natural healing response of quick, powerful inflammation bursts that heal damaged joints. The most obvious clue that healing has occurred is that the swelling goes away. 2018 Mar;98(5):1653-9. The anti-inflammatory effects of resveratrol make it a good remedy for arthritis, and skin inflammation. Inflammation becomes bad when the swelling does not go away. Wang G, Xie X, Yuan L, Qiu J, Duan W, Xu B, Chen X. Biofactors. Nutrients. The Paris Region had a GDP of 739 billion ($743 billion) in 2019, the highest in Europe. Resveratrol has been investigated for its potential use in preventing cancer and as an adjuvant (additional) therapy for cancer treatments. 2012;32(7):537-541. doi:10.1016/j.nutres.2012.06.003, Mahjabeen W, Khan DA, Mirza SA. (2014). conducted a clinical randomized controlled trial in 100 patients with RA (68 women, 32 men) in 2018, and the results support the addition of resveratrol as an adjuvant to traditional anti-rheumatic drugs (Khojah et al., 2018). IAA. See this image and copyright information in PMC. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: A clinical study. It has been discovered in different areas of the world, and resveratrol varies slightly from place to place (Cock and van Vuuren, 2014; Cock et al., 2015). Red Wine. In a recent study, resveratrol was shown to be effective in patients with RA. National Library of Medicine 2018;175(4):231-236. doi: 10.1159/000486959, Ratz-yko A, Arct J. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. (2014). Molecules. These parts of the grape are included in the fermentation of red wine, hence its particularly high concentration of resveratrol (5, 7). It may be helpful for hay fever and weight loss. They noted interesting results in terms of reduced tissue damage, restored cartilage homeostasis (cartilage stability), and decreased levels of uric acid (the problems with gout). 2022;66:102819. doi:10.1016/j.ctim.2022.102819, Hou CY, Tain YL, Yu HR, Huang LT. (2002). The supplement's potency can vary, depending on the amount of resveratrol in the supplement and manufacturer. Neuroprotective effect of trans-resveratrol in mild to moderate Alzheimer's disease: A randomized, double-blind trial. -, Alivernini S., MacDonald L., Elmesmari A., Finlay S., Tolusso B., Gigante M. R., et al. (2013). Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Resveratrol: Health Benefits, Safety Information, Dosage, and More - WebMD Some research suggests that taking smaller doses is better than taking one large dose, as resveratrol is metabolized quickly. Resveratrol has shown a wide range of biological activities in various in vitro and in vivo experiments, including antioxidant, anti-inflammatory, anti-cancer, anti-aging, and nervous system protection effects. Print 2018 Jun 29. In this study, we aimed to develop the preventive and therapeutic effect of resveratrol on gouty . Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. Research investigating the effects of resveratrol on metabolic function suggests that it may benefit metabolic health by helping regulate blood sugar levels and reducing insulin sensitivity, which may lower the risk of type 2 diabetes and other metabolic conditions. In addition, the expression of NF-B (p65) in the synovial tissue under dual treatment was significantly inhibited, with similar efficacy to that of the diclofenac group. Hao L., Wan Y., Xiao J., Tang Q., Deng H., Chen L., et al. (Wendling et al., 2015) found that in patients with RA, Sirt1 protein levels in peripheral blood mononuclear cells were lower than normal. Evolution of pain at 3 months by oral resveratrol in knee The answer some researchers brought forward? Declining trend in the incidence of rheumatoid factor-positive rheumatoid arthritis in Finland 1980-2000. Read our. Epub 2017 Aug 21. Int J Mol Sci. The self-assembly of QRU-PLGA-DS nanoparticles effectively improved the water solubility and targeting properties of resveratrol (RES) (Chen et al., 2019). In addition, resveratrol has been shown to protect mitochondria and regulate redox biology and kinetics in in vitro and in vivo experimental models. When swelling becomes chronic, the inflammatory factors that are beneficial to quickly heal, become corrosive over the long term, eroding joints. Chen X., Zhu X., Ma L., Lin A., Gong Y., Yuan G., et al. Resveratrol decreases FoXO protein expression through PI3K-Akt-dependent pathway inhibition in HO-treated synoviocytes. In addition, resveratrol has been shown to have therapeutic potential for RA complications, such as atrial remodeling and atrial fibrillation (AF). Yang G., Chang C., Yang Y., Yuan L., Xu L., Ho C., et al. Common food sources of resveratrol include: Resveratrol is available in capsule, tablet, powder, liquid, and gummy forms. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Kinins--key mediators in inflammatory arthritis? 26 (8), 12951306. A drug delivery system idea for resveratrol. In an abnormal toxic non-healing joint environment, nitric oxide production gets stuck in the open, position creating chronic damaging inflammation. Other research suggests that resveratrol may improve the function of the endotheliumthe inner lining of blood vesselshelping reduce vascular oxidative stress and stiffness in arteries, which helps promote healthy blood flow and protects against heart disease. Careers. Its shown promise regarding a variety of health conditions, including heart disease and arthritis. Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by symmetrical polyarthritis as its main clinical manifestation. (2004). On the other hand, BK/B2R/PKC Pathway and Nrf2/ARE/ROS pathway can act on downstream MAPK, which can mediate AP-1 and NF-B, thus forming a closed loop of complex signaling pathways starting from the SIRT1 pathway. In preclinical models of osteoarthritis and rheumatoid arthritis, resveratrol has shown joint protective effects, mainly mediated by decreased production of pro-inflammatory and pro-degradative factors. There is notable crosstalk between the SIRT1 and NF-B pathways, and these pathways, which play an essential role in the development of RA, are unexpectedly linked to the influence of resveratrol. MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. J Cosmet Laser Ther. Resveratrol also has other uses that haven't been studied by doctors to see if they work. Symmons D., Turner G., Webb R., Asten P., Barrett E., Lunt M., et al. Xu B., Wang G., Zhang J., Cao W., Chen X. Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant effects. [Google Scholar] The relief of histopathological injury by dual treatment was found to be greater than that by single treatment. Yeung F., Hoberg J., Ramsey C., Keller M., Jones D., Frye R., et al. Federal government websites often end in .gov or .mil. Resveratrol significantly inhibited interleukin (IL)1, IL6, and IL18 expression levels. These studies provide empirical evidence for the application of resveratrol in RA. (2016). The role of resveratrol on rheumatoid arthritis: From bench to bedside Supplements to Consider for Osteoarthritis of the Knee - Healthline In past research on RA, great attention has been paid to Th1; however, Th17 cells have attracted the interest of researchers due to their ability to produce a series of cytokines, such as IL17A, IL17F, IL21, IL22, and TNF, that greatly promote RA development. (2011). SIRT1 activity in ACPA-positive RA was lower than that in ACPA-negative RA (p = 0.01). Related experimental results have shown that resveratrol can significantly promote the apoptosis of these cells; therefore, resveratrol has the potential to alleviate and treat RA. SIRT1 participates in a wide variety of cellular processes; however, its molecular mechanism remains largely unknown. Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis. Health Benefits of Resveratrol and Should You Take It? 1. Resveratrol is a chemical mostly found in red grapes and products made from these grapes (wine, juice). Int J Mol Sci. Oxidative stress: a key modulator in neurodegenerative diseases, Resveratrol: A potential hippocampal plasticity enhancer. RATP: Public transport in Paris and le-de-France: metro, RER, bus, tramway But it doesn't seem to improve blood pressure, glucose control, or levels of cholesterol and. Currently, the pathogenesis of RA remains under discussion, and RA treatment is still at the bottleneck stage. It's generally safe to eat foods with resveratrol. Early research on resveratrol inhibition of the Wnt (Oz et al., 2019) and STAT3 pathways also provides new ideas, and the anti-inflammatory mechanism of resveratrol in these two pathways requires further investigation. Thank you, {{form.email}}, for signing up. Yang and Karsenty (Yang and Karsenty, 2002) reported PU.1 (a hematopoietic transcription factor) is required for macrophage differentiation, and SIRT1 has been shown to suppress PU.1. Resveratrol may interact with the following: Supplements and herbs that have similar effects or potential interactions with resveratrol include: To make an informed decision about resveratrol supplementation, carefully read the products ingredient list and nutrition facts panel, which provide information on the types and amounts of ingredients included. Please enable it to take advantage of the complete set of features! Szapyko W., Gromek I., Jzwiak S., Karkowska B., Skobejko-Wodarska L. (2003). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. and transmitted securely. Nature 319 (6053), 516518. PMC Would you like email updates of new search results? We control the inflammation through our regenerative injection techniques. Healing is not occurring. QRU-PLGA-RES-DS nanoparticles can effectively aggregate at the lesion site, promote the transformation of M2 macrophages, and reduce the recruitment of M1 macrophages, so as to effectively treat RA by eliminating an inflammatory response. However, research in Resveratrol continues to show benefits and the interest in Resveratrol could not be stronger as attested to by the numerous ongoing studies. Bertolini D. R., Nedwin G. E., Bringman T. S., Smith D. D., Mundy G. R. (1986). Resveratrol has an anti-apoptotic effect (an anti-oxidant characteristic of prevention of cell death, in this case, cartilage cell death), by shutting off harmful inflammation. It is worth noting that based on the above retrospective studies, this review also focuses on novel ideas and prospects for future clinical applications of resveratrol in combination with the latest research results and technologies in the field of life science and medicine. Federal government websites often end in .gov or .mil. What Are the Side Effects of Resveratrol? el-Dahr S., Dipp S., Yosipiv I., Baricos W. (1996). SIRT1 can downregulate NF-B and MMP1/MMP13, both of which promote the invasion of RA. (2019). RA prevalence varies geographically (Biver et al., 2009), and the disease is relatively rare in developing countries, such as rural West Africa, compared to North America and Northern Europe (Szapyko et al., 2003). Crowson C., Matteson E., Myasoedova E., Michet C., Ernste F., Warrington K., et al. Taking resveratrol by mouth seems to increase weight loss in overweight and obese adults. (2012). Accessibility Researchers say they aren't sure how closely connected grip strength and dementia are, but the link may have something to do with overall physical. Currently, resveratrol is considered to exert therapeutic effects on RA by activating silent information regulator 1 (SIRT1) and its downstream pathways. Oxid Med Cell Longev. Resveratrol significantly inhibited tumor necrosis factor. Chan S., Kantham S., Rao V., Palanivelu M., Pham H., Shaw P., et al. Protective effects of fenofibrate and resveratrol in an aggressive model of rheumatoid arthritis in rats. The effects of resveratrol in the treatment of metabolic syndrome. Plant-based supplements are being studied as a way to treat and prevent joint pain. Whether you're a long-distance runner or sick with a stomach bug, see our registered dietitian's picks of the best electrolyte powders in 2023. Understanding inflammation and healing so you can understand howResveratrol can help. Koushki M, Amiri-Dashatan N, Ahmadi N, Abbaszadeh HA, Rezaei-Tavirani M. Resveratrol: A miraculous natural compound for diseases treatment. (2019). Tellone E., Galtieri A., Russo A., Giardina B., Ficarra S. (2015). 31 (8), 509518. Nat. Resveratrol inhibits RA by promoting apoptosis. In addition, Cianciulli et al. 7 Health Benefits of Resveratrol Supplements Wendling D., Vidon C., Abbas W., Guillot X., Toussirot E., Herbein G., et al. Yoon J, Ku D, Lee M, Lee N, Im SG, Kim Y. Int J Mol Sci. Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production (13). No major risks have been revealed in studies that have used resveratrol supplements. Block the growth and spread of cancer cells, Boost the effectiveness of standard cancer treatments, such as chemotherapy and radiation therapy, Inhibit certain sex hormones to prevent the growth of hormone-dependent cancers, Gastrointestinal discomfort (e.g., nausea, vomiting, diarrhea, and abdominal pain), In a cool, dry place away from direct sunlight, heat, and humidity, In their original packaging and airtight containers, In a dark bottle to avoid light exposure, which may degrade the ingredients. As RA is characterized by a long duration and recurrent attacks, it may be possible to achieve long-term controlled release of resveratrol by wrapping the compound in polymer layers. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Zhou Q, Wang Y, Han X, Fu S, Zhu C, Chen Q. Efficacy of resveratrol supplementation on glucose and lipid metabolism: a meta-analysis and systematic review. Uncontrolled RA eventually leads to joint deformities and loss of function. [Google Scholar] It has shown effectiveness in treating conditions such as diabetes, Parkinson's disease, arthritis, cardiovascular illness, and pulmonary disease. (2013b). Adv Nutr. There is an urgent need to determine how to relate RSV to routine patient care. Basic research on resveratrol is well established; however, large-scale multi-center clinical trials are lacking, and the exact effective dose and safety concerns (side effects) are yet to be established. Furthermore, the migration and invasion abilities of RA-FLS were significantly inhibited by the downregulation of MMP1 and MMP13 expression (Gao et al., 2015; Jie et al., 2015). Lindsay Curtis is ahealth writer with over 20 years of experience in writing health, science & wellness-focused articles. Several studies have suggested that drinking red wine can help slow down age-related cognitive decline (21, 22, 23, 24). However, using the caspase 8 inhibitor z-IETD-fmk in RA-FLS cells can completely eliminate the apoptosis-promoting effect of resveratrol, whereas the caspase 3 inhibitor z-DEVDfmk only partially eliminates the apoptosis-promoting effect of resveratrol. A review of resveratrol as a potent chemoprotective and synergistic agent in cancer chemotherapy. 2021;10(2):905-917. doi:10.1007/s40120-021-00271-2. Currently, the pathogenesis of RA remains under discussion, and RA treatment is still at the bottleneck stage. Copyright 2022 Sheng, Wang, Liu, Hu, Shao, Wang, Mao, Li, Chen and Chen. Deoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients. Dose Response. When should I involve a Prolotherapist in my care? SIRT1 can downregulate NF-B and MMP1/MMP13,, Resveratrol inhibits RA by promoting apoptosis. Effects of resveratrol, curcumin and quercetin supplementation on bone metabolism-a systematic review. Introduction Currently available treatments for osteoarthritis (OA) are restricted to nonsteroidal anti-inflammatory drugs, which exhibit numerous side effects and are only temporarily effective. Byun H., Song J., Kim Y., Piao L., Won M., Park K., et al. When shopping for resveratrol supplements, choose a reputable brand, and follow the recommended dosage guidelines. What stresses a plant, you may ask? In the late stage, joint muscle atrophy, finger deviation to the ulnar side, metacarpophalangeal joint subluxation, and the appearance of swan neck and button patterns occurs. These clinical studies demonstrate that resveratrol plays an active role in RA. Meanwhile, a decrease in the mitochondrial membrane potential leads to a decrease in intracellular ATP production, which results in a gradual decrease in intracellular calcium release and influx (Cao et al., 2018). It may interact with certain medications and increase the risk of bruising and bleeding when taken with blood thinners, antiplatelet, and nonsteroidal anti-inflammatory drugs (NSAIDs). Suggested dose: The appropriate dose of resveratrol can vary depending on the condition it is used for. doi:10.1089/jmf.2017.4176, Sheng S, Wang X, Liu X, et al. A May 2020 study in the journal Cells (4) comes to us from Italy. The basic pathological changes include synovitis and pannus formation, progressive bone destruction, joint deformity, and loss of joint function ( Harris, 1990; Yanni et al., 1994; McInnes and Schett, 2011 ). On the other hand, resveratrol was found to be effective as an adjuvant in a study of the effects of methotrexate alone and in combination with resveratrol (cell viability test). Resveratrol is closely related to innate immunity and autoimmunity, which can reduce the number of immune cells and inhibit the function of immune cells through intact mechanisms. In the future, we believe that resveratrol will be used in additional large-scale applications. Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model. Nrf2-Keap1 pathway-mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide-treated rheumatoid arthritis fibroblast-like synoviocytes. 7 Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. (2017). If you are unsure how to store a particular resveratrol supplement, ask for guidance from your healthcare provider or contact the manufacturer directly. Inhibitory effect of baicalin on collagen-induced arthritis in rats through the nuclear factor-B pathway, Diagnosis and management of rheumatoid arthritis. The 10 Best Foods to Eat If You Have Arthritis - Healthline Price N. L., Gomes A. P., Ling A. J., Duarte F. V., Martin-Montalvo A., North B. J., et al. There have also been a handful of studies throughout the last few years that have focused solely on Resveratrols impact on inflammation and osteoarthritis. Mittal M., Mehta P., Rajput S., Rajender S., Chattopadhyay N. (2021). Nutrients. In addition to basic research studies, resveratrol has been widely used in clinical studies to activate SIRT1 to treat RA. They found that SIRT1 activity (nucleus and cytoplasm) was not related to Das28, CRP, ESR, or IL-8, but rather to baseline IL-6 (p = 0.02) and TNF (p = 0.04) in the RA and control groups. Researchers found the average total cholesterol levels and body weight of the mice decreased, and their levels of good HDL cholesterol increased (13). Marahleh A., Kitaura H., Ohori F., Kishikawa A., Ogawa S., Shen W. R., et al. In these studies, the prevalence rates in women were three times higher than those in men. Karimi A, Azar PS, Kadkhodayi M, Tandorost A, Vajdi M, Shoorei H, Farhangi MA. This finding suggests that resveratrol can inhibit the PMA-induced phosphorylation and nuclear translocation of PU.1, thus inhibiting monocyte differentiation into macrophages (Buhrmann et al., 2017). The shell was composed of a thermosensitive molecular poly (lactic-glycolic acid) (PLGA) that was modified by the target molecule dextran sulfate (DS). . (2018). Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. In another study, resveratrol effectively relieved joint inflammation and damage in people with rheumatoid arthritis (RA). Naturally occurring polyphenolic compounds, such as curcumin and resveratrol, are potent agents for modulating . If you currently use medications, then you may want to check with a doctor before trying resveratrol. What Happens If I Take Too Much Resveratrol? This study was supported by the Natural Science Foundation of Anhui Province (No 2108085MH264, chaired by XC), the innovation training program for college students in Anhui Province (s202110366032, chaired by SS) and the early contact scientific research training program for undergraduates in Anhui Medical University (2021-zqky-101, chaired by SS). (2016). Here are a few more benefits resveratrol may have for people with diabetes (28): Resveratrol may even provide more benefits for people with diabetes than those who dont have it. (2005). Disease, fungus, environmental pollutants to name a few. Legal status: Resveratrol is available as a dietary supplement in the United States and is not regulated by the FDA as a drug. In our practice inflammation is THE tool to fix damaged joints. If youve heard that red wine can help lower cholesterol, chances are youve heard of resveratrol the much-hyped plant compound found in red wine. University researchers publishing in the medical journal Molecular Medicine Reports (1)had a lot of good things to say aboutResveratrol. Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells, Resveratrol and its effects on the vascular system. 2019;21(2):84-90. doi:10.1080/14764172.2018.1469767, Abu-Amero KK, Kondkar AA, Chalam KV. The pro-apoptotic function of resveratrol depends mainly on the caspase pathway. Research suggests that resveratrol may be an effective complementary therapy and help reduce joint pain in people with osteoarthritis. 2023 Healthline Media LLC. Resveratrol has a chondroprotective (cartilage protective) characteristic that helps limit cartilage matrix loss (the cartilage ingredients) during the early stages of the disease. Fiber intake depends on age, gender, and sex. In 2007, it was reported that the injection of resveratrol effectively reduced cartilage damage in an experimental arthritis model (RA) induced by lipopolysaccharide (LPS) (Elmali et al., 2007). 5 Marouf BH, Hussain SA, Ali ZS, Ahmmad RS. However, its not clear if the compound would have a similar effect in humans. Vodka is considered a lower-calorie libation compared to wine or beer, but is it the best option for those trying to lose weight? 8600 Rockville Pike RSV inhibits the expression of BCL XL in MH7A cells and promotes SIRT1 mediated apoptosis; which enhances the activation of caspase 8 in fls-85 cells, both of which can cause the efficient release of cytochrome c in mitochondria, activate caspase 9 and caspase 3, and promote apoptosis (Byun H. S. et al., 2008; Nakayama et al., 2012b; Nguyen N. T. et al., 2015). Resveratrol has antioxidant and anti-inflammatory properties that help alleviate symptoms of all these types of arthritis. One study injected resveratrol into the knee joints of rabbits with arthritis and found that these rabbits suffered less damage to their cartilage (34). (2004). (1994). Epub 2022 Jun 27. The RA molecular regulation chain surrounding SIRT1. Its always best to review the supplement label with your healthcare provider so they can help you identify any potential interactions with foods, medications, or other supplements. Wu YJ, Fang WJ, Pan S, Zhang SS, Li DF, Wang ZF, Chen WG, Yin Q, Zuo J. Int Immunopharmacol. Specifically, the goal is to deliver the right amount of drug to the right place at the right time, to increase the efficiency of drug use, improve efficacy, reduce costs, and reduce side effects. Therefore, resveratrol can reduce the production of COX-2 and function as a powerful drug against RA (Tsai et al., 2017; Yang et al., 2017; Dudics et al., 2018a). Int J Mol Sci. Resveratrol benefits, dosage, and more - Medical News Today The QRU-PLGA-RES-DS nanoparticles significantly enhanced the ability of RES to reverse M1-TYPE macrophages to M2-TYPE macrophages by precision release. Furthermore, a microarray analysis showed that RSV also affects the expression of DNA replication-related genes, p53 pathway genes, PDGF signal pathway genes, ccna2, and rhoj in RA-FLS (Glehr et al., 2013b). Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt. If you take very high doses of resveratrol, you may experience side effects or adverse events such as: Seek medical attention if you suspect you have taken too much resveratrol. Relieve joint pain due to osteoarthritis. 2018;6(8):2473-2490. doi:10.1002/fsn3.855, Salehi B, Mishra AP, Nigam M, et al. HHS Vulnerability Disclosure, Help Heres how resveratrol may combat cancer cells: However, since the studies so far have been carried out in test tubes and animals, much more research is needed to see if and how this compound might be used for human cancer therapy.
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