Therefore, we and other investigators suggest that vitamin D sufficiency be defined as serum 25-OHD 30 ng/mL (16). increase renal calcium excretion. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Pediatric doses must be individualized (see DOSAGE AND ADMINISTRATION). Adults2 drops or 0.05 milliliters (mL) once a day. Patients with early-stage renal disease should be able to convert vitamin D to 25-OHD. DESCRIPTION Vitamin involved in calcium and phosphate balance and normal bone growth and mineralization Found in fortified milk and cereal products, fish, liver, and egg yolks Used for prevention and treatment of vitamin D deficiency and rickets COMMON BRAND NAMES DeVille J, Thorp ML, Tobin L, Gray E, Johnson ES, Smith DH. US residents can call their local poison control center at 1-800-222-1222. Kaiser Permanente health plans around the country: Kaiser Foundation Health Plan, Inc., in Northern and Southern California and Hawaii Kaiser Foundation Health Plan of Colorado Kaiser Foundation Health Plan of Georgia, Inc., Nine Piedmont Center, 3495 Piedmont Road NE, Atlanta, GA 30305, 404-364-7000 Kaiser Foundation Health Plan of the Mid-Atlantic States, Inc., in Maryland, Virginia, and Washington, D.C., 2101 E. Jefferson St., Rockville, MD 20852 Kaiser Foundation Health Plan of the Northwest, 500 NE Multnomah St., Suite 100, Portland, OR 97232 Kaiser Foundation Health Plan of Washington or Kaiser Foundation Health Plan of Washington Options, Inc.,1300 SW 27thSt., Renton, WA 98057. WARNING: DO NOT EXCEED RECOMMENDED DOSAGE. Evaluation of Vitamin D Repletion Regimens to Correct Vitamin D Status Medically reviewed by Drugs.com. Ergocalciferol is a white, colorless crystal, insoluble in water, soluble in organic solvents, and slightly soluble in vegetable oils. 2023 Kaiser Foundation Health Plan, Inc. We are unable to switch you to this area of care. Ergocalciferol Dosage Guide + Max Dose, Adjustments - Drugs.com If your doctor has recommended that you follow a special diet (such as a diet high in calcium), it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Bottles of 100 capsules (NDC 42794-006-02). respond differently from younger subjects. Take this medicine only as directed by your doctor. Guide to bone health and disease in cystic fibrosis. A loop diuretic This information does not assure that this product is safe, effective, or appropriate for you. Mineral oil interferes with the absorption of fat-soluble vitamins, including vitamin D preparations. Vitamin D deficiency, insufficiency, and sufficiency were defined as a serum 25-OHD level of <20 ng/mL, 21 to 29 ng/mL, and 30 ng/mL, respectively. Sunscreen, protective clothing, limited exposure to sunlight, dark skin, and age may prevent getting enough vitamin D from the sun. Basile LA, Taylor SN, Wagner CL, Horst RL, Hollis BW. Soft Tissues: Widespread calcification of the soft tissues, including the heart, blood vessels, renal tubules, and lungs. The treatment of hypervitaminosis D with hypercalcemia consists of immediate 0 to 12 months: 10 mcg (400 international units) orally daily Publication types Comparative Study MeSH terms Adolescent Adult Aged Aged, 80 and over Dose-Response Relationship, Drug Drug Evaluation Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). It may be best to take ergocalciferol after a meal, but you may take ergocalciferol with or without food. Make sure laboratory personnel and all your doctors know you use this drug. Tell your doctor right away if any of these signs of high vitamin D/calcium levels occur: A very serious allergic reaction to this drug is rare. Consult your pharmacist or local waste disposal company. Careers, Unable to load your collection due to an error. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. National Library of Medicine Blood calcium and phosphorus Ergocalciferol is a white, colorless crystal, insoluble in water, soluble in organic solvents, and slightly soluble in vegetable oils. Effect of ergocalciferol supplementation on serum parathyroid hormone and serum 25-hydroxyvitamin D in chronic kidney disease. VITAMIN D (Ergocalciferol Capsules, USP)1.25mg (50,000 USP Units) Animal reproduction studies have shown fetal abnormalities in several species Vitamin D sufficiency was defined as 25-OHD 30 ng/mL, and toxicity was defined as 25-OHD >150 ng/mL or a calcium level 1.0 mg/dL above the reference range (or both findings) (14). phosphate from bone and probably increase the reabsorption of calcium and Advertising revenue supports our not-for-profit mission. DailyMed - ERGOCALCIFEROL capsule It is available in multiple generic and brand versions. Adams JS, Kantorovich V, Wu C, Javanbakht M, Hollis BW. The https:// ensures that you are connecting to the There is increased awareness for the high prevalence of vitamin D insufficiency in the general population of the United States. 50,000 IU Capsule DESCRIPTION DRISDOL brand of ergocalciferol capsules, USP, is a synthetic calcium regulator for oral administration. the contents by NLM or the National Institutes of Health. associated with hypervitaminosis D. These are similar to the supravalvular Patients in the first 2 quartiles (indicating the greatest increase in 25-OHD) had higher final 25-OHD values and had more study subjects reach vitamin D sufficiency (Table 4). Hypercalcemia with anorexia, nausea, weakness, weight loss, vague aches and stiffness, constipation, mental retardation, anemia, and mild acidosis. Spina CS, Tangpricha V, Uskokovic M, Adorinic L, Maehr H, Holick MF. Vitamin D metabolites also mobilize calcium and phosphate from bone and probably increase the reabsorption of calcium and perhaps also of phosphate by the renal tubules. In the current study, we sought to determine which vitamin D repletion regimens were in use at a large academic-affiliated Veterans Affairs Medical Center (VAMC). Ergocalciferol, also called vitamin D2, is 9, 10-secoergosta-5, 7, 10 (19), 22-tetraen-3-ol,(3,5Z,7E,22E)-; (C28H44O) with a molecular weight of 396.65, and has the following structural formula: The in vivo synthesis of the major Fig. Data sources include IBM Watson Micromedex (updated 14 May 2023), Cerner Multum (updated 28 May 2023), ASHP (updated 10 Apr 2023) and others. The range between therapeutic and toxic doses is narrow, and this medication should be given under close medical supervision. Ergocalciferol may be only part of a complete program of treatment that also includes dietary changes and taking calcium and vitamin supplements. It is affected by air and by light. We also found that PTH levels do not consistently decrease after treatment of vitamin D insufficiency. Search for vitamins and natural medicines, Request for confidential communications forms, Learn more about link terms and conditions, itching/swelling (especially of the face/tongue/throat), high calcium/vitamin D levels (hypercalcemia/hypervitaminosis D), difficulty absorbing nutrition from food (malabsorption syndrome). This product contains FD&C Yellow No. In some cases, there may be a very small difference in amount between safe and dangerous doses of this medicine. This list is not complete. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Do not take other supplements/vitamins unless ordered by your doctor. when no permanent damage has occurred. of the active metabolites in the liver and kidneys. Vitamin D2 is much less effective than vitamin D3 in humans. In addition to treatment regimen, we also tested total dose of vitamin D received, rapidity of repletion, timing of dose (monthly, weekly, daily, and so forth), and dosing regimen (using the 4 most common methods) as potential exposure variables, with vitamin D sufficiency as the outcome variable. The prescribed dose of ergocalciferol ranged from 400 IU to 50,000 IU, and the frequency of dosing ranged from twice daily to once monthly. Comments: Recommended Daily Allowance: 15 mcg (600 international units) daily Brand names: Calcidol, Calciferol, Drisdol, Vitamin D2 Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Evaluation of Ergocalciferol or Cholecalciferol Dosing, 1,600 IU Daily National Kidney Foundation K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease. metabolites promote the active absorption of calcium and phosphorus by the small Over 70 years: 20 mcg (800 international units) orally daily Tolerable Upper Intake Level: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The .gov means its official. A single 100,000-IU oral dose of vitamin D3 yielded 60% higher 25-OHD levels at 5 weeks in comparison with placebo (mean, 14.2 and 7.7 ng/mL, respectively) (29). Tell your doctor if you are pregnant or if you become pregnant while taking ergocalciferol. The recommended adequate intakes of vitamin D published by the Institute of Medicine (400 to 600 IU or 10 to 15 g daily) for most adults are inadequate to maintain or correct vitamin D status in vitamin D-insufficient adults (14). perhaps also of phosphate by the renal tubules. Ergosterol or provitamin D2 is found in plants and yeast and has no antirachitic activity. Use the dropper that comes with the package to measure your dose. Ergocalciferol is a white, colorless crystal, insoluble in water, soluble in organic solvents, and slightly soluble in vegetable oils. stiffness, constipation, mental retardation, anemia, and mild acidosis. 50,000 to 200,000 international units (1250 to 5000 mcg) orally daily, concomitantly with calcium lactate 4 g, six times per day No international standard has been established for vitamin D sufficiency, and some studies suggest 30 ng/mL should be the minimal level for sufficiency (18,19). We also tested the effect of initial 25-OHD in the model; it was not significant at the 5% level. Selected fromNATIONAL DRUG DATA FILE (NDDF)data included with permission and copyrighted by First Databank, Inc., 2019. Call your doctor for medical advice about side effects. Less serious side effects may be more likely, and you may have none at all. Ergocalciferol is vitamin D2. It is affected by air and by light. Hypoparathyroidism: 50,000 to 200,000 IU units daily concomitantly with calcium lactate 4 g, six times per day. The 3 most common regimens were ergocalciferol 50,000 IU once weekly for 4 weeks followed by 50,000 IU once monthly for 5 months (n = 48); ergocalciferol 50,000 IU once monthly for 6 months (n = 80); and ergocalciferol 50,000 IU 3 times weekly for 6 weeks (n = 27). Always ask your health care professional for complete information about this product and your specific health needs. Vitamin D with calcium is used to treat or prevent bone loss (osteoporosis). The safety in excess of 400 USP Units of vitamin D daily during pregnancy has not been established. Serum PTH and calcium levels were not significantly affected by any of these 3 prescribing modalities. No long-term animal studies have been performed to evaluate the Package insert / product label Vitamin D metabolites also mobilize calcium and If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Drug class: Vitamins. Before using this medication, tell your doctor or pharmacist your medical history, especially of: Liquid products, chewable tablets, or dissolving tablets may contain sugar and/or aspartame. Drisdol (Ergocalciferol Capsules): Uses, Dosage, Side Effects - RxList The safety in excess of 400 USP units of vitamin D daily during pregnancy has not been established. SigmaPharm Laboratories, LLC. Follow all directions on your prescription label and read all medication guides or instruction sheets. Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with Ergocalciferol Capsules, USP may cause hypercalcemia. Clinical studies of ergocalciferol capsules did not include Vitamin D2 (Ergocalciferol) 1.25mg Capsules (50,000 IU) Ergosterol or provitamin D2 is found in plants and yeast and has no antirachitic activity. In Argentinean children, a single 150,000-IU oral dose of ergocalciferol safely maintained 25-OHD levels at a mean of 18.7 ng/mL but did not improve serum PTH concentrations (31). Only 1 patient in our study reached vitamin D sufficiency with use of the vitamin D2 50,000-IU once weekly regimen; therefore, we are unable to draw conclusions regarding its efficacy. vessels, renal tubules, and lungs. Call your doctor for medical advice about side effects. Ergocalciferol Monograph for Professionals - Drugs.com Large oral or parenteral doses of vitamin D3 (cholecalciferol) have been shown to increase and sustain higher 25-OHD levels. Ergocalciferol is also used to treat rickets (softening of the bones caused by vitamin D deficiency) or low levels of phosphate in the blood (hypophosphatemia). . Version: 5.03. Hypoparathyroidism: 50,000 to 200,000 USP units daily concomitantly with . This medication passes into breast milk. In all 4 treatment regimens analyzed, the mean corrected calcium from before to after treatment with ergocalciferol differed no more than 0.2 mg/dL (Table 2). Vitamin D at normal doses usually has no side effects. Vitamin D is used to treat and prevent bone disorders (such as rickets, osteomalacia). Do not double the dose to catch up. Open in a separate window. Ergocalciferol - Side Effects, Uses, Dosage, Overdose - RxWiki 5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible individuals. DOSAGE MUST BE INDIVIDUALIZED UNDER CLOSE MEDICAL SUPERVISION. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Blood calcium and phosphorus determinations must be made . In a mother given large doses of vitamin D, 25-hydroxycholecalciferol appeared in the milk and caused hypercalcemia in her child. The green colored oval shaped transparent soft gelatin capsules are imprinted with '194' in white and contain clear light yellow oily liquid. The first DOSAGE MUST BE INDIVIDUALIZED UNDER CLOSE MEDICAL SUPERVISION. Do not swallow whole wafers. The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. increased mineralization of bones in infants and children (dwarfism) vague In contrast, Holick et al (37) recently demonstrated that vitamin D2 and vitamin D3 were equally efficacious in raising 25-OHD concentrations when given as a daily 1,000-IU dose. withdrawal of the vitamin, a low calcium diet, generous intake of fluids, along Ergocalciferol Uses, Side Effects & Warnings - Drugs.com Renal: Impairment of renal function with Sign In HDPE Bottles of 100 capsules (NDC 23155-809-01) sufficient numbers of subjects aged 65 and over to determine whether they Take your next dose at the regular time. DOSAGE MUST BE INDIVIDUALIZED UNDER CLOSE MEDICAL SUPERVISION. ergocalciferol capsules may cause hypercalcemia. Of the 35 subjects in their study who received that treatment regimen, only 21 (60%) had posttreatment 25-OHD levels >30 ng/mL, a proportion similar to that seen in our review. All authors contributed to the design of the study, the analysis of the data, and the writing of the manuscript. Calciferol (Ergocalciferol): Uses, Dosage, Side Effects - RxList Other reported therapeutic measures include dialysis or the administration of citrates, sulfates, phosphates, corticosteroids, EDTA (ethylenediaminetetraacetic acid), and mithramycin via appropriate regimens. 0 to 6 months: 25 mcg (1000 international units) daily, 7 to 12 months: 38 mcg (1500 international units) daily, 1 to 3 years: 63 mcg (2500 international units) daily, 4 to 8 years: 75 mcg (3000 international units) daily, 9 years and older: 100 mcg (4000 international units) daily. The dose of this medicine will be different for different patients. irreversible renal insufficiency which may result in death. 2. Vitamin D2 (ergocalciferol): Uses, Side Effects, Dosage & Reviews - GoodRx VITAMIN D (Ergocalciferol Capsules, USP) 1.25 mg (50,000 USP Units) supplements, self-administered and prescription drug sources should be An overdose could cause serious or life-threatening side effects. Additionally, a 10-day high-dose course of ergocalciferol (50,000 IU daily) showed sustained elevation in 25-OHD levels at 4 months (32). This syndrome was characterized by supravalvular aortic stenosis, elfin facies, and mental retardation. Uses Warnings Before taking Side effects Interactions Dosage What is ergocalciferol? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Your doctor may adjust your dose as needed. on the cap and body. One of the limitations of this study is our lack of data on cholecalciferol. We evaluated the effects of total ergocalciferol dose on changes in 25-OHD, PTH, and calcium. syndrome was characterized by supravalvular aortic stenosis, elfin facies, and Monitoring of the infant's serum calcium concentration is required in This outcome suggests that there may be a difference in vitamin D preparations when given in pharmacologic versus physiologic doses in the resultant increase in 25-OHD levels. Cholecalciferol (vitamin D3) is not widely available in strengths higher than 2,000 IU. If you are taking the rapidly-dissolving tablets, dry your hands before handling the medication. Institute of Medicine. Calcium intake should be adequate. Vitamin D constipation. We also examined a popular regimen recommended by Malabanan et al (12)ergocalciferol 50,000 IU per week for 8 weeksas treatment 4 (total of 400,000 IU). Learn more about link terms and conditions. should be avoided unless, in the judgment of the physician, potential benefits aches, stiffness, and weakness. PDF DRISDOL Prescribing Information - Sanofi January 27, 2022 What is vitamin D2 (ergocalciferol)? The effects of administered vitamin D can Decline in the average rate of linear growth and increased mineralization of bones in infants and children (dwarfism). The safety in excess of 400 USP Units of vitamin D daily during pregnancy has not been established. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Register, The photos shown are samples only One USP unit of vitamin D2 is equivalent to one International Unit (IU), and 1 mcg of vitamin D2 is equal to 40 IU. This regimen, however, was devised when the target for 25-OHD was greater than 20 ng/mL; thus, it is likely that this regimen is inadequate. evaluated. Do not store in the bathroom. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. osteodystrophy is essential to prevent metastatic calcification. Animal reproduction studies have shown fetal abnormalities in several species associated with hypervitaminosis D. These are similar to the supravalvular aortic stenosis syndrome described in infants by Black in England (1963). Parathyroid hormone is CLINICAL PHARMACOLOGY The - in vivo synthesis of the major biologically active metabolites of vitamin D occurs in two steps. Nursing Mothers. X-rays of the bones should be taken every month until condition is corrected and stabilized. The 3 most common prescribing modalities were ergocalciferol 50,000 IU once weekly for 4 weeks followed by 50,000 IU once monthly for 5 months (total of 450,000 IU) (treatment 1, n = 48); ergocalciferol 50,000 IU once monthly for 6 months (total of 300,000 IU) (treatment 2, n = 80); and ergocalciferol 50,000 IU 3 times weekly for 6 weeks (total of 900,000 IU) (treatment 3, n = 27). Studies have demonstrated that serum 25-OHD levels of 30 to 32 ng/mL result in maximal suppression of PTH, optimal intestinal calcium absorption, and prevention of fractures (1,20-22). Other reported clinical experience Therapeutic dosage should be readjusted as soon as there is clinical Dosage form: capsule Of the 265 patients included in this study, 66% had both pretreatment and posttreatment 25-OHD levels. Armas LA, Hollis BW, Heaney RP. Although not statistically significant, a trend existed toward a lower body mass index in quartile 1, the subset of patients with the most robust increase in mean 25-OHD levels. An official website of the United States government. appropriate regimens. In a mother given large doses of vitamin D, 1Division of General Internal Medicine, Emory University School of Medicine, Atlanta, Georgia, 2Division of Endocrinology, Diabetes and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, 4Staff Physician, Endocrinology, Department of Veterans Affairs Medical Center, Atlanta, Georgia, 3Division of Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University School of Medicine, Atlanta, Georgia. The mean duration for all vitamin D repletion regimens was 116 62 days, with a range of 7 to 196 days. We created 4 quartiles based on percentage increase of 25-OHD. D2 50,000 IU twice weekly provided the most rapid attainment and highest mean levels of vitamin D. Abbreviations: 25 (OH)D = 25-hydroxyvitamin D; BMI = body mass index; BUN = blood urea nitrogen; Ca/Cr = calcium/creatinine; D2 = ergocalciferol; D3 = cholecalciferol; IU = international units; PTH = parathyroid hormone. Properly discard this product when it is expired or no longer needed. Khaw KT, Scragg R, Murphy S. Single-dose cholecalciferol suppresses the winter increase in parathyroid hormone concentrations in healthy older men and women: a randomized trial. Talk to your pharmacist for more details. Canada residents can call a provincial poison control center. Hypoparathyroidism: 50,000 to 200,000 USP Units daily concomitantly with calcium lactate 4 g, six times per day. DESCRIPTION ERGOCALCIFEROL CAPSULES, USP, is a synthetic calcium regulator for oral administration. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: This is not a complete list of possible side effects. Data sources include IBM Watson Micromedex (updated 14 May 2023), Cerner Multum (updated 28 May 2023), ASHP (updated 10 Apr 2023) and others. The patients were classified into 3 groups based on total dosage of ergocalciferol: 300,000 IU; 300,001 to 599,999 IU; and 600,000 IU. To determine the relative efficacy of different amounts of vitamin D on correcting vitamin D insufficiency, we used PROC LOGISTIC (logistic procedure) in SAS to calculate odds ratios to compare 3 total amounts of vitamin D used in the repletion regimen (300,000 IU, 300,001 to 599,999 IU, and 600,000 IU), with 600,000 IU as the reference group. DailyMed - VITAMIN D- ergocalciferol capsule Written by Cerner Multum. Blood calcium and phosphorus . You do not need to take this medication with water. Conflicting reports have been published about vitamin D sufficiency and its effects on serum PTH in patients with chronic kidney disease. Mayo Clinic does not endorse companies or products. Adequate Follow us on these external social media sites that will open in a new browser window. Some examples of published regimens for the correction of vitamin D status in healthy adults include 50,000 IU of ergocalciferol once a week for 8 weeks (12) or 50,000 IU of ergocalciferol twice a week for 5 weeks (13). We identified 36 discrete prescribing regimens. Clinical studies of Ergocalciferol Capsules, USP did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. to hypoparathyroid patients who are concurrently being treated with D) and the second in the kidneys (to 1,25-dihydroxyvitamin D). Diamond TH, Ho KW, Rohl PG, Meerkin M. Annual intramuscular injection of a megadose of cholecalciferol for treatment of vitamin D deficiency: efficacy and safety data. An annual 600,000-IU intramuscular injection yielded sustained improvement in 25-OHD levels >20 ng/mL at 4 and 12 months in conjunction with a modest decrease in PTH value (30). The publisher's final edited version of this article is available at. The green colored oval shaped transparent soft gelatin capsules are imprinted with '194' in white and contain clear light yellow oily liquid. DailyMed - ERGOCALCIFEROL capsule, liquid filled In 174 patients, 25-OHD was determined both before and after vitamin D repletion. In these cases vitamin D must be strictly restricted. persist for two or more months after cessation of treatment. (%), Correction of vitamin D insufficiency 30 ng/mL, No. This result suggests that the frequency of dosing may not matter as much as the total dose administered over time. In general, dose selection for an elderly patient should be Judd SE, Nanes MS, Ziegler TR, Wilson PW, Tangpricha V. Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey. improvement. Your medication may look different. All rights reserved. Calcium intake should be adequate. Review of all the prescribed regimens in our hospital disclosed no case of vitamin D toxicity. Each capsule contains Vitamin D (Ergocalciferol) 1.25 mg equivalent to 50,000 USP Units. Drug class: Vitamins. Your doctor will determine how long to treat you with this medicine. Redefining vitamin D insufficiency. Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. To compare the association of serum 25-OHD changes with PTH changes, we used a linear regression with log-transformed dependent and independent variables to account for nonnormality. DOSAGE MUST BE INDIVIDUALIZED UNDER CLOSE MEDICAL SUPERVISION. Use only the recommended dose of ergocalciferol. Liquid products may also contain alcohol. Ergocalciferol (vitamin D2) Oral Reviews and User Ratings - WebMD
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